Network Medicine

The exposome and health: Where chemistry meets biology


Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is needed. The “exposome” concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stressors, and physical factors, as well as their corresponding biological responses. Technological advances such as high-resolution mass spectrometry and network science have allowed us to take the first steps toward a comprehensive assessment of the exposome. Given the increased recognition of the dominant role that nongenetic factors play in disease, an effort to characterize the exposome at a scale comparable to that of the human genome is warranted.


More publications
Italo F. do Valle, Harvey G. Roweth, Michael W. Malloy, Sofia Moco, Denis Barron, Elisabeth Battinelli, Joseph Loscalzo & Albert-László Barabási

Nature Food volume 2, pages143–155(2021)

Soodabeh Milanlouei, Giulia Menichetti, Yanping Li, Joseph Loscalzo, Walter C. Willett & Albert-László Barabási

Nature Communications volume 11, Article number: 6074 (2020)

Albert-László Barabási, Giulia Menichetti & Joseph Loscalzo

Nature Food 1, 33-37 (2019)