Network Medicine

Impact of the solvent capacity constraint on E. coli metabolism

Obtaining quantitative predictions for cellular metabolic activities requires the identification and modeling of the physicochemical constraints that are relevant at physiological growth conditions. Molecular crowding in a cell's cytoplasm is one such potential constraint, as it limits the solvent capacity available to metabolic enzymes.


More publications
K.-I. Goh, M. E. Cusick, D. Valle, B. Childs, M. Vidal, A.-L. Barabási

Proceedings of the National Academy of Sciences 104:21, 8685 (2007)

A. Vazquez, J.G. Oliveira, Z. Dezso, K.I. Goh, I. Kondor, A.-L. Barabási

Physical Review E 73, 036127 (2006)

M. A. Yildirim, K.-L. Goh, M.E. Cusick, A.-L. Barabási, M. Vidal

Nature Biotechnology 25:10, 1119-1126 (2007)