Network Medicine

Evolutionary conservation of motif constituents in the yeast protein interaction network

Understanding why some cellular components are conserved across species but others evolve rapidly is a key question of modern biology1-3. Here we show that in Saccharomyces cerevisiae, proteins organized in cohesive patterns of interactions are conserved to a substantially higher degree than those that do not participate in such motifs. We find that the conservation of proteins in distinct topological motifs correlates with the interconnectedness and function of that motif and also depends on the structure of the overall interactome topology. These findings indicate that motifs may represent evolutionary conserved topological units of cellular networks molded in accordance with the specific biological function in which they participate.


More publications
Deisy Morselli Gysi, Ítalo do Valle, Marinka Zitnik, Asher Ameli, Xiao Gan, Onur Varol, Susan Dina Ghiassian, J. J. Patten, Robert A. Davey, Joseph Loscalzo, and Albert-László Barabási

PNAS May 11, 2021 118 (19) e2025581118

Italo F. do Valle, Harvey G. Roweth, Michael W. Malloy, Sofia Moco, Denis Barron, Elisabeth Battinelli, Joseph Loscalzo & Albert-László Barabási

Nature Food volume 2, pages143–155(2021)

Soodabeh Milanlouei, Giulia Menichetti, Yanping Li, Joseph Loscalzo, Walter C. Willett & Albert-László Barabási

Nature Communications volume 11, Article number: 6074 (2020)